Nigeria's Paralympic champion Esther Oyema looked comfortable as she first equalled, then broke, her own world record twice on the way to victory in the women's -55kg.
The 31-year-old opened with 120kg, before lifting 123kg in round two to break the record she set in Kuala Lumpur in November 2013.
With a third-round flourish, Oyema hauled 125kg to further her world mark.
China's Shanshan Shi (115kg) finished in silver, whilst Russia's Anastasia Khonina (109kg) took bronze.
The junior title went to 19-year-old Italian Martina Barbierato (70kg).
The 2014 IPC Powerlifting World Championships, featuring over 330 athletes from nearly 60 countries, run from 5-11 April and are the first opportunity for athletes to begin qualification for the Rio 2016 Paralympic Games.
The competition also features the climax to the "Raise the Bar campaign," which has seen powerlifters and team officials take part in education seminars as part of efforts to reduce doping in the sport.
More information including a full competition schedule and live results can be found at the Dubai 2014 website: http://www.paralympic.org/dubai-2014